Why not? If you want to put the effort in to make it, of course.
Column on right is obviously possible. Removal of all the borders on panels is also straightforward. Wider right block column isn't too hard.
Using templates and CSS you should be able to approach the News layout - if not you certainly can with Pro_News.
Ordered list and unordered list are in the nBBCode mod I believe.
I'd suggest that you take a look at reDesign template and use it as a base, as it is very clean already, if not yet the minimalist layout that you're after. And I'm finding it fairly easy to modify - it's all CSS.
Would be some new work to create the blockquote look, but clearly it's all possible,
Hadn't checked your www, see you are already halfway there - the reDesign theme
Attached please find a cleaned up version of your no_avatar.gif - I couldn't stand that white edge
Some reading, yeah, but diving in may work nearly as well, then google for what you need. Start with installing web developer for Firefox, as it lets you view which CSS statement is being employed for each item as you mouse over, among a whole lot of other useful features.
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